Further Observations on the Effects of Autonomic Blocking Agents in Patients with Hypertension
نویسنده
چکیده
Moderate reduction in blood pressure by intravenous hexamethonium or pentamethonium was accompanied by a decrease in stroke volume, cardiac output, and left ventricular work, and no change or an increase in peripheral resistance. Renal blood flow, filtration rate, and potassium clearance fell promptly, but returned to the original levels within one to two hours despite continued reduction in blood pressure. Sodium clearance and urine flow were reduced to a greater extent and returned more slowly. Oral hexamethonium produced some reduction in renal blood flow, and improvement in the ballistocardiogram. Oral hydrazinophthalazine diminished the effect of hexamethonium on renal blood flow.
منابع مشابه
Further Observations on the Efects of Autonomic Blocking Agents in Patients with Hypertension
lopathy than in those with benign hyl)ertension. Concurrent administration of hvrciazinophthalazine resulted in an additive effect on the blood pressure of most l)atients, with slower. development of tolerance and less markedl postural hvpotension. In many patients there was improvement in signs ancl symptoms attributable to lhypertension. Harmful effects of reduction in bloo1( pressure occurre...
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